Eine aus vielen Partikel bestehende pharmazeutische Zusammensetzung zur Maskierung des Geschmacks, die aus einem einen Wirkstoff enthaltenden Kern und einer Membran nach einer Lösungsmittelcoazervation enthält

Une composition pharmaceutique multiparticulaire pour masquer le gout - contenant un noyau avec un principe actif et une membrane gràce à une coacervation avec un solvant

Taste-masked multiparticulate pharmaceutical composition comprising a drug-containing core particle and a solvent-coacervated membrane

Abstract

There is provided a method for preparing an orally disintegrating tablet (ODT) composition comprising microparticles of one or more taste-masked active pharmaceutical ingredients, rapidly-dispersing microgranules, and other optional, pharmaceutically acceptable excipients wherein the ODT disintegrates rapidly with saliva in the buccal cavity forming a smooth, easy-to-swallow suspension. Furthermore, the microparticles (crystals, granules, beads or pellets containing one or more actives) with a taste-masking membrane applied by a modified solvent coacervation process comprising a water-insoluble polymer and at least one gastrosoluble inorganic or organic pore-former, exhibit a pleasant taste when placed in the oral cavity and provide rapid, substantially-complete release of the dose on entry into the stomach.

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